BeautyBio's patented R45 The Reversal 3-phase retinol booster system is clinically proven to reduce the appearance of wrinkles - in one 45-day treatment. Key Ingredients TriGLO: Concentrations of our deep-release retinol complex increase with each phase for a clinically proven reduction in the appearance of wrinkles, skin tone unevenness, skin spots and pore size Growth Factor Stimulant Serum: Peptide complex that strengthens skin