the box is a little damaged due to shipping but uts brand new. Patented R45 The Reversal 3-Phase Retinol Booster System from BeautyBio is clinically proven to reduce the appearance of wrinkles - in one 45-day treatment. How To Use On clean skin, apply one pump of side A and one pump of side B from Phase 1 to face (layer or mix together) and repeat nightly until bottle is empty (should take about two weeks). Please recycle component once finished. After Phase 1, advance to Phase 2 then Phase 3. Results are cumulative, do not start with Phase 3. Follow immediately with your favorite moisturizer. Details Key Ingredients TriGLO: concentrations of Beautybio's deep-release retinol complex increase with each phase for a clinically proven reduction in the appearance of wrinkles, skin tone unevenness, skin spots and pore size Growth Factor Stimulant Serum: Peptide complex that strengthens skin's proteins, increases hydration levels and fortifies skin against free radical damage Citric Acid: Boosts collagen production and diminishes the appearance of dark spots and age spots Safflower Seed Oil: Combines with skin's sebum to unclog pores, reduce breakouts, and create a protective barrier to retain moisture